A Study to Learn More About Improving Mesenchymal Stem Cells and Its Application in Chronic Kidney Disease Due to Hypertensive Nephropathy

Overview

About this study

The purpose of this study is to investigate the central hypothesis that autologous, adipose-derived MSC preconditioned by hypoxia will have superior kidney angiogenic function compared to untreated MSC from humans with HN and CKD.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

All subjects eligible for this study will meet the following inclusion criteria:

Age between 18 to 80 years
Estimated GFR ≥15 mL/min/1.73m²
Ability to provide consent and complete all aspects of the study

Exclusion Criteria:

Subjects will be excluded from participation if they have any of the following exclusion criteria:
Diabetes Mellitus
Pregnant
Evidence of hepatitis B or C, or HIV infection (this will be assessed through the EMR)
Solid organ transplantation
Nephrotic syndrome
Immunosuppression therapy
Active glomerulonephritis
Autosomal dominant or recessive polycystic kidney disease
Known RVD
Active malignancy to minimize interference of underlying conditions or treatments on MSC functionality.
Subjects on therapeutic doses of anticoagulants [Rivaroxaban (Xarleto); Apixaban (Eliquis); Dabigatran (Pradaxa, Prazaxa)].
History of substance abuse (including alcohol) within the past 2 years
Active substance abuse (>3 alcoholic beverages/day or>21 per week)
Body weight >150 kg or BMI >50
Uncontrolled psychiatric disorder

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Sandra Herrmann, M.D.	Closed for enrollment	Contact information: Department of Medicine – Clinical Trials Unit (507) 266-1944 RSTDOMCTU@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Sandra Herrmann, M.D.

Closed for enrollment

Contact information:

Department of Medicine – Clinical Trials Unit

(507) 266-1944

RSTDOMCTU@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials