Thyroid Autoimmunity Biobank

Overview

About this study

We plan to create a databank of serum and tissue samples from patients with thyroid autoimmunity, mainly focusing on Graves’ disease and Graves’ orbitopathy, respectively. This set of samples will allow us to study these disorders better in the laboratory as well as test potential agents that can be used as therapies.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Graves' Disease
- ≥18 years of age
- TSH < 0.1 mIU/L
- RAI scan and uptake: symmetric bilateral and>% LLN
- Total T4 > 11.7 mcg/dL /total T3 > 200 ng/dL or Free T4 level: ≥1.7 ng/dL
Painless Thyroiditis
- ≥18 years of age
- TSH < 0.1 mIU/L
- Thyroid uptake < 3%
- Total T4 > 11.7 mcg/dL /total T3 > 200 ng/dL or Free T4 level: ≥1.7 ng/dL
- Absence of iodine exposure, neck pain
- Note: immunomodulatory therapy should be mentioned clinically
Subacute Thyroiditis
- ≥18 years of age
- TSH < 0.1 mIU/L
- Thyroid uptake < 3%
- Total T4 > 11.7 mcg/dL /total T3 > 200 ng/dL or Free T4 level: ≥1.7 ng/dL
- Absence of iodine exposure
- Presence of neck pain, elevated ESR > ULN for age
- Note: immunomodulatory
Hashimoto’s Thyroiditis
- ≥18 years of age
- TSH > 4.2 mIU/L
- TPO antibodies >9 IU/L or ULN for the assay
- US pattern or cytology or pathology consistent with HT
Graves’ Orbitopathy
- ≥18 years of age
- Presence of manifestations for GO, both inactive and active (CAS≥3)
- History of autoimmune thyroid disease
- CT/MRI consistent w/ GO
Healthy Controls Serum
- ≥18 years of age
- No personal or family history of thyroid disease
- Normal TSH cascade
- No use of medication known to affect thyroid function
- Normal thyroid exam
Orbital Controls
- ≥18 years of age
- Patients that are scheduled to undergo orbital decompression for non-autoimmune conditions (e.g. normal pressure hydrocephalus, trauma etc.)
Pretibial Myxedema
- ≥18 years of age
- Diagnosis of PTM on clinical grounds, confirmed in Dermatology

Exclusion Criteria:

Graves' Disease
- Prior treatment with thyroidectomy or radioiodine or concurrent treatment with anti-thyroid drugs (preferred newly diagnosed patients).
- Pregnancy
Painless Thyroiditis
- Pregnancy
Subacute Thyroiditis
- Pregnancy
Hashimoto’s Thyroiditis
- Absence history of RAI therapy or external radiation to thyroid; absence thyroid cancer history
- Pregnancy
Graves’ Orbitopathy
- History of radiation to orbits; immunomodulatory therapy except oral steroids (>4 weeks off)
- Pregnancy

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Marius Stan, M.D.	Closed-enrolling by invitation What is this? (?) "Close" Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.	Contact information: Paula Giesler R.N. (507) 255-8345 Giesler.Paula@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Marius Stan, M.D.

Closed-enrolling by invitation

Contact information:

Paula Giesler R.N.

(507) 255-8345

Giesler.Paula@mayo.edu

More information

Publications

Publications are currently not available

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