Clinical Trials

Inclusion Criteria:

ADPKD patients

• ADPKD (based on Ravine et al. criteria).
• Class 1 B according to our imaging classification.
• Male and female subjects 18-30 years of age, inclusive.
• Estimated GFR> 60 mL/min/m^2 (CKD-EPI equation).
• Ability to provide written, informed consent.

Healthy Volunteers

• Male and female subjects 18-30 years of age, inclusive.
• Estimated GFR > 60 mL/min/m^2 (CKD-EPI equation).
• Ability to provide written, informed consent.

Exclusion Criteria:

ADPKD patients

• Class 2 according to our imaging classification.
• Concomitant systemic disease in the kidney (e.g., lupus, hepatitis B or C, amyloidosis).
• Diabetes mellitus (fasting glucose > 126 mg/dL or treatment with insulin or oral hypoglycemics).
• Predicted urine protein excretion in urinalysis >1 g/24 hours.
• Abnormal urinalysis suggestive of concomitant glomerular disease.

Healthy Volunteers

• Previous personal or family history of kidney disease.
• Concomitant systemic disease in the kidney (e.g., lupus, hepatitis B or C, amyloidosis).
• Diabetes mellitus (fasting glucose > 126 mg/dL or treatment with insulin or oral hypoglycemics).
• Presence of proteinuria.
• Abnormal urinalysis suggestive glomerular disease.