Clinical Trials

Inclusion Criteria:

• All subjects who are managed by the Mayo Clinic HEN program for enteral nutrition.
• Require EN support for at least 4-6 weeks from enrollment.

Exclusion Criteria:

• Patients with type 1 or 2 diabetes will be excluded due to the known pre-existing changes in the gut microbiome in this population.
• All patients will not have had exposure to probiotics, prebiotics or antibiotics in the preceding 4 weeks.
• Known allergy or intolerance to study products.
• On parenteral nutrition.
• Oral feeding accounts for > 25% of calories.
• Presence of entero-cutaneous fistula.
• Short bowel syndrome.
• Bariatric surgery or other alteration of GI tract.
• Hematologic malignancy with absolute neutrophil count < 500/mm^3.
• History of renal or liver transplant or on transplant list.