Follow-on Study of Coagulation Function in Patients with AERD (Aspirin Exacerbated Respiratory Disease)

Overview

About this study

The purpose of this study is to better characterize the extent the pathways involved in AERD (leukotriene, prostaglandin, and thromboxane) impact coagulation pathways.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Patients with high index of suspicion for diagnosis of AERD; i.e., asthma, presence of chronic rhinosinusitis with nasal polyps and history of reaction/intolerance to aspirin or NSAIDS (Non-steroidal anti-inflammatory drugs).
Symptom burden suggesting presence of active disease.These would essentially be patients with total SNOT-22 more than 7 (normal).
Evaluation in ENT and/or Allergy Clinic with confirmation of chronic sinusitis and/or nasal polyposis.
Willingness to undergo a blood draw for twolab measures.

Exclusion Criteria:

Patients with asthma, nasal polyps, who lack a clear history suggestive of ASA sensitivity.
Patients with well controlled AERD (total SNOT-22 scores <7) or past history of ASA desensitization with ongoing therapy.
Patients on 5-LO antagonists (Zileuton).
Patients on anti-coagulation.
Patients on systemic steroids 6 weeks prior to assessment.
Women of childbearing age who are pregnant.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Erin O'Brien, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Erin O'Brien, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

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