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A Study to Determine the Best Individualized Cancer Therapy Using Circulating Tumor DNA (ctDNA) in Patients with GI, CNS, and Thoracic Cancers.

Overview

About this study

This study proposes to develop and maintain a biorepository of blood samples collected from patients receiving definitive chemoradiotherapy for locally advanced rectal cancer, locally advanced pancreatic cancer, non-small cell lung cancer, or cervical cancer. The ultimate goal of this biorepository will be to provide the resource to initiate an exploration of ctDNA as a potential liquid biopsy for GI and Thoracic malignancy detection and surveillance.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  1. Adult patients (> 18 years of age) receiving definitive chemoradiotherapy at Mayo Clinic Florida
  2. Patients with tumors with a risk of local persistence of disease after therapy in the following areas:
    1. Locally advanced rectal cancer (T3-4NxM0; TxN+M0)
    2. Locally advanced non-small cell lung cancer
    3. Locally advanced pancreatic cancer
    4. High grade brain and spine tumors
    5. Locally advanced cervical cancer treated with primary radiotherapy

Exclusion Criteria: 

  1. Adult patients not willing/able to provide informed consent
  2. Patients <18 years of age
  3. Patients with HIV infection or Hepatitis infection

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Byron May, M.D.

Closed for enrollment

Contact information:

Anna Harrell M.P.H.

Harrell.Anna@mayo.edu

More information

Publications

Publications are currently not available

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CLS-20438430

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