Clinical Trials

Inclusion Criteria:

• Enrollment in Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (The PROCEED Study).
• Participant will be undergoing an MRI of the pancreas for clinical indications OR will be undergoing an MRI of the pancreas for research as part of their participation in the PROCEED Study.
• All participants must sign an informed consent indicating that they are aware of the investigational nature of this study and are willing to undergo MRI evaluation, and authorizing the use of their protected health information for research purposes.

Exclusion Criteria:

• Age < 18 or >75 years old.
• Weight ≥ 350 lbs.
• Evidence of dense calcific CP, as detected on any abdominal imaging study (the presence of < 10 punctuate calcifications measuring < 3mm is not an exclusion), verified by a CPDPC site radiologist.
• Presence of >3 cm peri-pancreatic fluid collection.
• Prior documented allergy to secretin.
• History of moderate or severe allergic reaction to gadolinium-based contrast agent.
• Pregnancy.
• Documented history of inflammatory bowel disease or vagotomy.
• Active, acute pancreatitis flare.
• Claustrophobia and/or need for general anesthesia to undergo MRI.
• History of acute kidney injury within the preceding 6 weeks, with no confirmation that serum creatinine has returned to normal.
• Known estimated glomerular filtration rate (eGFR) < 45 ml/min/1.73m2.
• Severe COPD limiting breath-holding for MRI.
• Moderate or large volume ascites (of any etiology).
• Known hemochromatosis.
• Known cystic fibrosis homozygosity.
• History of splenectomy.
• Patients with therapeutic body implants; specifically, pacemakers, defibrillators, or other implanted electronic devices that are not MRI-compatible will be excluded. Patients with an IVC filter, body piercing, neurosurgical clip placement, or shrapnel injury will be evaluated on an individual basis.
• Unwilling or unable to give written, informed consent.