Clinical Trials

Inclusion Criteria: 

• Must have CDASI Activity score of greater than or equal to 14, and have failed at least 1 standard of care systemic treatment, (e.g., corticosteroids). 
• Confirmation of DM by the investigator and two of the following:
  • Gottron's papules;
  • Gottron's sign;
  • Heliotrope eruption;
  • Nailfold changes, (dilated capillary loops, capillary dropout, cuticular hypertrophy and/or rugged cuticles;
  • Photodistributed violaceous erythema, (skin that is exposed to sunlight and appears purplish/reddish, and patchy in appearance;
  • Positive DM serology. 
• Post DM diagnosis; standard of care workup for DM must have been completed prior to entry into this research study. 
• Willing to provide 6 biopsies during the course of the research study.

Exclusion Criteria: 

• Investigator site staff or members of their family. 
• Acute and Chronic present medical conditions. 
• Intake of greater than 15 mg of prednisone or equivalent per day. 
• Pregnant or breastfeeding females. Fertile men and women who will not comply with the use of 2 effective birth control methods as per the research protocol. 
• Have required management of acute or chronic infections. 
• Have pre-existing demyelinating disorder such as multiple sclerosis, or other severe neurological deficits. 
• Clinically significant lab abnormalities.
• Any health condition that may be worsened by immunosuppression.