Clinical Trials

Inclusion Criteria:

• Will utilize the Mayo Clinic Biobank to identify randomly- selected individuals encompassing the age span of 25-65 years old.
• No history of diabetes.
• Reside within a 100 mile radius of Mayo Clinic, Rochester, MN.
• Individuals who have expressed interest in participating in research will then be contacted and invited to participate in the study.

Exclusion Criteria:

• Age < 25 or > 65 years old (to avoid studying subjects who could have latent type 1 diabetes or the effects of age extremes in subjects with normal or impaired fasting glucose).
• HbA1c ≥ 6.5%.
• Use of glucose-lowering agents.
• For female subjects, positive pregnancy test at the time of enrollment or study.
• History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
• Active systemic illness or malignancy.
• Symptomatic macrovascular or microvascular disease.
• Hormone therapy >0.625 mg premarin daily.