Find trials
Search tips

Brain Imaging Changes Following Proton Therapy for Pediatric Primary Central Nervous System and Base of Skull Tumors

Overview

About this study

The purpose of this study is to evaluate LET-based modeling as an early and accurate predictor for white-matter changes as identified on MRI and DTI in pediatric patients with primary central nervous system and skull base malignancies following proton beam therapy

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

- Patients must have histologically confirmed central nervous system of skull base
tumors

- Patient is going to undergo central nervous system (CNS) or base of skull proton beam
therapy

Exclusion Criteria:

- Patients who have received prior therapeutic radiotherapy to the primary brain tumor
site

- Patients who are unable to maintain follow-up through the Phoenix Children's Hospital
and Mayo Clinic Arizona

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 2/2/24. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Tamara Vern-Gross, D.O.

Closed for enrollment

Contact information:

Cancer Center Clinical Trials Referral Office

(855) 776-0015

More information

Publications

Publications are currently not available

More about research at Mayo Clinic

.
CLS-20463515

Mayo Clinic Footer