Clinical Trials

Inclusion Criteria:

• Histologically confirmed primary or recurrent invasive breast cancer with plans for adjuvant radiation therapy at the Mayo Clinic.
• Oligometastatic breast cancer (≤ 3 sites of metastases) is permitted provided that the disease is managed with curative intent.
• Patients treated with lumpectomy or mastectomy.
• Patients must have indication for regional nodal irradiation.
• Age 18 or older.
• Willingness to provide informed consent and expresses understanding of this protocol and its requirements, risks, and discomforts.
• Patients must have completed their final breast surgery including re-excision of margins for invasive cancer and DCIS or chemotherapy within 90 days prior to registration but no sooner than 21 days prior to the initiation of radiation therapy (RT).
• Bilateral breast cancer is permitted.
• Positive or close margins is allowed.

Exclusion Criteria: 

• Other active malignancy ≤ 2 years prior to registration (exceptions: non-melanotic skin cancer or carcinoma-in-situ of the cervix).
• Pregnancy or lactation.
• Inability on the part of the patient to understand the informed consent to be compliant with the protocol.