Clinical Trials

Inclusion Criteria:

• Male and female spontaneous aSAH patients  admitted to the Neuroscience Intensive Care Unit (NeuroICU) at Mayo Clinic Florida
• ≥ 18 years of age.
• Intracranial aneurysm documented by computed tomography (CT) angiogram, formal cerebral angiogram or magnetic resonance (MR) angiogram and deemed to be the cause of the SAH by the treating NeuroICU attending or Neurosurgeon. Alternatively initially angiogram negative SAH suspicious for other vascular cause including pretruncal/perimesencephalic, suspect arteriovenous malformation (AVM) or dural AV fistula may be included.
• Ability to draw repeated blood samples via arterial, central or other venous line, and possibly timed with CSF draws via an external ventricular drain (EVD) if placed as standard of care for management of symptomatic hydrocephalus by the treating neurosurgeon. The EVD must be deemed functional by the surgeon to allow for sampling of CSF via aseptic, sterile technique or the drip chamber. Similarly, if a lumbar drain (LD) is placed by the treating neurosurgeon and/or neurointensivist team and functional this can be used to acquire CSF samples.
• Modified Fisher scale severity of bleeding grade 3 or 4.

Exclusion Criteria: 

• Traumatic SAH.
• Pregnant or breastfeeding females.