Clinical Trials

Inclusion Criteria

1. Adults females and males older than 18 years-old
2. Patients under opioid medication or other pain-relievers for at least 3 months
3. Patients who successfully complete the 3-weeks IPR program
4. Patients who successfully withdrawal any type of opioid-based treatment
5. Patients who signed informed consent

Exclusion criteria

1. Subjects who do not complete the IPRP
2. Subjects under any type of hormone replacement therapy
3. Prior diagnosis of adrenal insufficiency, hypogonadism or sexual hormones dysregulation
4. Immunocompromised patients
5. Patients with current pregnancy
6. Patients with current hormonal therapy/ replacement
7. Subjects who have undergone surgical intervention in the past 30 days
8. Subject has history of cancer requiring active treatment in the last 6 months prior to baseline