Investigating the Link Between Type 2 Immunity and NAFLD in Human Obesity- AIM 1

Overview

About this study

This study is being done to better understand the relationship between inflammation in your AT, abnormal deposition of fat around your liver and how this affects its appearance and function and ultimately insulin resistance.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

- Undergoing gastric bypass surgery

- Confirmed AUROC F=0 or F>2 liver fibrosis

- Age 30-70 years

- BMI greater than 40 kg/m2

- Negative pregnancy test (female only)

- Lab Values: Normal TSH

Exclusion Criteria:

- Autoimmune diseases

- Hepatitis B or C positive

- Heavy alcohol use

- Active smoking history

- Active cancer history

- History of asthma

- History of COPD

- Taking Plavix or Coumadin

- Blood donation within past 2 months

- Glucocorticoid Therapy

- Taking antihistamine on regular basis

Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Eligibility last updated 5/1/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Scottsdale/Phoenix, Ariz. Mayo Clinic principal investigator Elena Anna De Filippis, M.D., Ph.D.	Open for enrollment	Contact information: Keegan Stewart M.S. (480) 301-4164 Stewart.Keegan@mayo.edu

Mayo Clinic Location

Status

Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Elena Anna De Filippis, M.D., Ph.D.

Open for enrollment

Contact information:

Keegan Stewart M.S.

(480) 301-4164

Stewart.Keegan@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials