A Study to Evaluate Left and Right Ventricular Function in Relation to Exercise Capacity in Breast Cancer Survivors

Overview

About this study

The purpose of this study is to determine if exercise improves cardiac remodeling as a way to mitigate the negative effects of chemotherapy and radiation therapy which lead to reduced exercise tolerance.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Females ≥ 18 years of age.
Females treated for breast cancer (BC) with left breast radiation and chemotherapy which must have included an anthracycline dosed at 60 mg/m2 for 4 cycles.
Date of last exposure to chemotherapy or radiation therapy > 1 year.

Exclusion Criteria:

Age < 18 years
Pregnancy
Mechanical ventilation
Acute or chronic renal failure (creatinine clearance < 30 ml/min or on renal replacement therapy
Inability to perform MRI (claustrophobia, severe morbid obesity, non-MRI compatible implanted devices
Inability to exercise
Significant arrhythmia that precludes adequate ECG-gating for the MRI (atrial fibrillation with a highly variable cycle length)
Left ventricular systolic dysfunction (ejection fraction < 50%) or diastolic failure based on Framingham criteria for heart failure with preserved ejection fraction.
Significant left-sided valvular disease (moderate to severe aortic valve stenosis, mitral valve stenosis, aortic regurgitation, mitral regurgitation, or prior valve surgery) .
History of congenital heart defect with or without repair.
Exposure to chemotherapy for a malignancy other than breast cancer.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Jacksonville, Fla. Mayo Clinic principal investigator Brian Shapiro, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Jacksonville, Fla.

Mayo Clinic principal investigator

Brian Shapiro, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

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