Clinical Trials

Inclusion Criteria:  Group # 1 (ONLY POTS):

• Adolescents between ages of 13 and 18 years.
• Patients will complete the three week Pediatric Pain Rehabilitation Center program.
• POTS will be identified on the basis of accepted criteria (chronic symptoms of orthostatic intolerance, with heart rate increase of greater than 40 beats per minute or more with head up tilt, in the absence of orthostatic hypotension).
• For this study, the diagnosis will have been made on the basis of autonomic reflex screening performed at Mayo Clinic.
• No-Chronic pain. Chronic pain is identified as pain lasting more than 12 weeks; at the point of referral to the PPRC, pain is identified as causing functional impairment. 
• Patients will have the ability to assent for the participation in the research study.

Exclusion Criteria: 

• Documented disability including developmental delay, cognitive disability, blindness, deafness, paralysis, or psychosis.
• Metal implants, such as pacemakers or braces
• Women cannot be pregnant or breastfeeding.
• Patients will be excluded if they do not complete the three week PPRC program.

Inclusion Criteria: Group # 2 (POTS and Chronic Pain):

• Adolescents between ages of 13 and 18 years.
• Patients will complete the three week Pediatric Pain Rehabilitation Center program.
• POTS will be identified on the basis of accepted criteria (chronic symptoms of orthostatic intolerance, with heart rate increase of greater than 40 beats per minute or more with head up tilt, in the absence of orthostatic hypotension). For this study, the diagnosis will have been made on the basis of autonomic reflex screening performed at Mayo Clinic.
• Chronic pain is identified as pain lasting more than 12 weeks; at the point of referral to the PPRC, pain is identified as causing functional impairment. 
• Patients will have the ability to assent for the participation in the research study.

Exclusion Criteria: 

• Documented disability including developmental delay, cognitive disability, blindness, deafness, paralysis, or psychosis.
• Metal implants, such as pacemakers or braces
• Women cannot be pregnant or breastfeeding.
• Patients will be excluded if they do not complete the three week PPRC program.

Inclusion Criteria: Group # 3 (Chronic Pain Alone):

• Adolescents between ages of 13 and 18 years.
• Patients will complete the three week Pediatric Pain Rehabilitation center Program
• No POTS diagnosis.
• Chronic pain is identified as pain lasting more than 12 weeks at the point of referral to the PPRC; pain is identified as causing functional impairment.
• Patients will have the ability to assent for the participation in the research study.

Exclusion Criteria: 

• Documented disability including developmental delay, cognitive disability, blindness, deafness, paralysis, or psychosis.
• Metal implants, such as pacemakers or braces.
• Women cannot be pregnant or breastfeeding.
• Patients will be excluded if they do not complete the three week pediatric Pain Rehabilitation Center Program.

Inclusion Criteria: Control Group

• Adolescents between ages of 13 and 18 years.
• Patients will have the ability to assent for the participation in the research study.

Exclusion Criteria:

• Documented disability including developmental delay, cognitive disability, blindness, deafness, paralysis, or psychosis.
• Metal implants, such as pacemakers or braces.
• Women cannot be pregnant or breastfeeding.
• Any active acute or chronic medical condition.

Inclusion Criteria: Parent Group

• Be a parent or legal guardian of a recruited participant for this study.
• Be able to provide informed consent to participate.

Exclusion Criteria:

• Documented disability including developmental delay, cognitive disability, blindness, deafness, paralysis, or psychosis.