A Study to Assess the Diagnosis, Gender Prevalence, Management and Outcomes of Cough Hypersensitivity Syndrome

Overview

About this study

The purpose of this study is to identify the burden of Cough Hypersensitivity Syndrome (CHS) diagnosis made after a comprehensive evaluation for chronic cough at the Mayo Clinic Rochester, to evaluate the gender difference in our chronic cough referrals and for the diagnosis of CHS, to assess a subset of chronic cough patients with cough related urinary incontinence, related to gender difference and as an outcome after treatment, and to assess the number of patients treated with neuromodulator agents and the clinical outcome including adverse reactions.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Adult patients (≥ 18 years old) referred to our Mayo Clinic chronic cough specialty clinic.
Diagnosis of chronic cough > 8 weeks as per ACCP guidelines. This could include different etiologies such as cough variant asthma, eosinophilic bronchitis, GERD, UACS and CHS.
Chronic refractory cough or unexplained cough for at least 1 year prior to screening per American College of Chest Physicians/ British Thoracic Society (ACCP/BTS) guidelines.

Exclusion Criteria:

Patients without research authorization.
Patients < 18 years of age.
Patients with acute respiratory tract infection.
Patients with asthma or COPD exacerbation at the visit.
Pregnant or lactating women.
Active smokers using cigarettes, vaping or electronic cigarettes.
Patients on use of angiotensin receptor inhibitors.
Patients with pulmonary fibrosis.
Patients with bronchiectasis.
Patients with lung cancer.
Patients in their end of life care.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Sumera Ahmad, M.B.B.S.	Closed for enrollment	Contact information: Hope Marlow (507) 538-3423 Marlow.Hope@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Sumera Ahmad, M.B.B.S.

Closed for enrollment

Contact information:

Hope Marlow

(507) 538-3423

Marlow.Hope@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials