A Study to Evaluate the Role of WNT/b-catenin Signaling in Human Alveolar Macrophages (AMs) in Adjusting Inflammation

Overview

About this study

The purpose of this study is to determine whether WNT/b-catenin signaling is upregulated in alveolar macrophages (AMs) in children following exposure to common viral or bacterial pathogens that cause acute lower respiratory tract infections (LRTIs). We will also probe underlying respiratory and circulating immunological mechanisms contributing to the differences of disease severity between pediatric and elderly populations following COVID-19 infection.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Children 0-18-years-old.
Children who undergo flexible bronchoscopy with BAL as above part of their clinical management.

Exclusion Criteria:

Exclusion criteria for the control and PBB groups included the presence of hereditary.
Respiratory diseases (such as cystic fibrosis), clinical history of primary aspiration, neuromuscular problems.
Primary or secondary immune deficiencies, invasive infections such as Mycobacterium tuberculosis.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Jie Sun, Ph.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Jie Sun, Ph.D.

Closed for enrollment

More information

Publications

Publications are currently not available

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