Clinical Trials

CONTROLS

Inclusion Criteria:

• Consent obtained.
• Age ≥ 40 years in NOMAD study.
• Normal colonoscopy within past 5 years.

Exclusion Criteria:

• Known history of non-cutaneous (except for melanoma) cancer within prior 5 years (or new cancer emerging within 3 years following blood draw).
• Inability to provide blood sample.

CASES

Inclusion Criteria:

• Newly diagnosed or recurrent stage II-IV CRC seen on imaging and confirmed by histology (Note: Bloods may be drawn in patients with suspected recurrence on imaging and prior to histologic report, but final inclusion will require histological confirmation of recurrent tumor) OR patients with stage II-IV CRC on current systemic treatment (chemo or radiation therapy) here for imaging studies as routine treatment monitoring, OR patients currently with no evidence of disease (NED) from resected stage II CRC, resected stage III CRC, or stage IV CRC with complete surgical resection, and confirmed by imaging and histology.
• Consent obtained and able to provide blood samples.
• Age ≥ 18 years.

Exclusion Criteria:

• Inability to provide blood sample.
• Known history of non-cutaneous (except for melanoma) cancer outside of the colon within prior 3 years.

RETROSPECTIVE STUDY ON ARCHIVAL TUMOR SPECIMENS

CASES

Inclusion Criteria:

• Consent recorded in record.
• Age ≥ 18 years.

Exclusion Criteria:

• History of radiation to site of tumor being studied
• Known familial cancer syndrome (e.g. Lynch syndrome, familial adenomatous polyposis)

CONTROLS

• Buffy coat specimens as negative controls.