Assessment of ProEnkephalin to Detect Acute Kidney Injury (AKI) in Patients Hospitalized for Volume Overload Decompensated Chronic Heart Failure

Overview

About this study

The purpose of this study is to evaluate the baseline presence of plasma levels of biomarkers of renal injury and changes in these biomarkers during the course of in-hospital intravenous diuretic therapy can predict when threshold values that would indicate a clinically significant change in renal function that would warrant a change in diuretic therapy to occur.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Age >18 years
LVEF <50% measured within 6 months of index hospitalization
Clinically identified volume overload with at least one sign of volume overload (pre-admission fluid weight gain, edema, increased DOE, PND, orthopnea, JVD on examination) and a need for intravenous diuretic therapy

Exclusion Criteria:

Baseline sCr>3.0mg/dL and K+<3.0 and >5.5mEq/L
Hemoglobin <9.0g/dL
Systemic systolic blood pressure consistently <100mm Hg
Patients being treated with hemodialysis, CKD state 5 or s/p renal transplantation
S/P cardiac transplant or LVAD implantation/total artificial heart
Pregnancy or of child bearing potential
Allergy to iodine
Unable to provide informed consent to participate in the study

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Paul McKie, M.D.	Closed for enrollment	Contact information: Jacqulyn Reiter (507) 255-9524 Reiter.Jacqulyn@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Paul McKie, M.D.

Closed for enrollment

Contact information:

Jacqulyn Reiter

(507) 255-9524

Reiter.Jacqulyn@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials