Clinical Trials

Inclusion Criteria:

• Age: 2.5 years - 18 years
• Healthy controls recruited either from schools, from the environment of the investigator or from siblings of patients seen at the pediatric rheumatology clinic.
• Consecutive patients visiting the pediatric rheumatology clinic with confirmed diagnosis of one of the following systemic autoimmune/inflammatory disease:
  • JIA, according to ILAR criteria2.
  • Juvenile Systemic Sclerosis (jSSc), according to the new preliminary classification criteria of JSSc3.
  • Juvenile localized Sclerosis (jlSc), based upon clinical judgment
  • Pediatric onset MCTD, according to Alarcon-Segovia or Kasukawa4, 5.
  • Definite diagnosis of childhood-onset systemic lupus erythematosus (cSLE), according to ACR classification criteria or SLICC criteria6, 7.
  • Suspected diagnosis of cSLE, fulfilling less than 4 criteria of ACR or SLICC.
  • Juvenile dermatomyositis (JDM), according to Bohan and Peter diagnostic criteria8.
  • Vasculitis, according to EULAR/PRINTO/PRESS9.
  • Auto-inflammatory diseases, based upon clinical judgment.

Exclusion Criteria:

• Subject who gave no consent.
• Patient does not fulfill the proposed criteria at time of entry in the study