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Ptosis after Plaque

Overview

About this study

The Ptosis after Plaque Radiotherapy (PtaP) study involves investigation of the effect of plaque radiotherapy surgery on upper eyelid position. The study investigates clinical and imaging data prior to and 4 months following plaque radiotherapy and examines the frequency and degree of upper eyelid blepharoptosis. Comparison will be made to filtering glaucoma surgery, which involves similar operative time and manipulation of extraocular muscles and Tenon’s fascia. The fellow eye will be used as a no treatment control. This study will provide new data to improve the understanding of blepharoptosis as a side effect of plaque radiotherapy. This study involves a simple ruler measurement of eyelid position prior to and 4 months after surgery that is performed by the treating physician as part of the patient’s standard of care office visit. This study does not involve any experimental tests and does not require any additional office visits or cost for the patient or the practice.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients will be recruited during routine visits from the ocular oncology and glaucoma services.
  • Cases: Subjects with an intraocular tumor undergoing primary treatment with plaque radiotherapy.
  • Controls: Subjects with glaucoma undergoing filtering surgery (tube shunt or trabeculectomy).
  • Age 18 years or older at the time of recruitment.
  • Ability to understand and willingness to sign the informed consent documents.

Exclusion Criteria:

  • Under 18 years of age.
  • Unable or unwilling to sign or understand the informed consent documents.
  • Unwilling to participate in the research.
  • Prior history of blepharoptosis or eyelid surgery before study enrollment.
  • Not meeting the inclusion criteria.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Lauren Dalvin, M.D.

Open for enrollment

Contact information:

Lauren Dalvin M.D.

Dalvin.Lauren@mayo.edu

More information

Publications

Publications are currently not available

More about research at Mayo Clinic

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CLS-20502814

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