Clinical Trials

Inclusion Criteria:

• ≥ 18 and ≤ 45 years of age.
• Asymptomatic individuals who vape at least once a week for the past 6 months or longer OR individuals with non-urgent symptoms possibly related to vaping whose symptom onset occurred during at least weekly vaping use for 3 months or longer (non-urgent is defined as in the opinion of the investigator or primary care physician, the patient does not require urgent/emergent medical care for symptom management).
• Current vapers or those vapers who have quit within the past 30 days.
• If subject is referred by a physician as a symptomatic patient, his or her health history, medications, review of symptoms, and physical exam are available in Epic EMR and would have been updated within the past 30 days.
• Subject is a never smoker - defined as having used less than 100 cigarettes in their lifetime.
• Able to fully participate in all aspects of the study.
• Able to understand and sign the consent.
• Negative pregnancy test if female (available through our study coordinator).
• Mayo Clinic patient with a primary care physician who can be contacted if medical attention to CT findings is needed.

Exclusion Criteria:

• Smoked a cigarette/s within the past 30 days.
• With the exception of asthma, has a known medical condition that causes or can cause lung findings including but not limited to heart disease, liver or kidney failure, amyloidosis, cancer (excluding non-melanoma skin cancer), HIV, immunosuppression, bleeding disorders, cystic fibrosis, emphysema, or any interstitial lung disease.
• An upper respiratory infection (includes nasal congestion with cough), pneumonia or influenza within the past 30 days.
• Chronic respiratory symptoms prior to the start of vaping.
• With the exception of vaping marijuana and THC products, participants must have not use illicit drugs including IV drugs and smoked marijuana.
• Has an unstable or urgent medical condition as determined by the physician investigator.
• Expired air carbon monoxide > 8 ppm.
• Patient needs to be less than 50 cm across at top of liver as measured by the CIC staff.