A Study to Evaluate Circadian Regulation of Human Adipose Tissue Metabolism

Overview

About this study

The purpose of this study is to determine the nutrient independent role of adipocyte specific circadian rhythmicity in controlling adipocyte function in humans, to determine the impact of central obesity on adipocyte circadian clock, and to establish for the first-time adipocyte specific direct target genes of the core circadian clock transcription factors, BMAL1 and CLOCK.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Aim 1

Normal weight, sedentary males and females.
Age ≥ 18 and ≤ 55 years old.
BMI of 20-25 kg/m^2 (male BMI < 22 are often too lean to obtain adequate adipose tissue).

Aim 2

Upper body obesity (UBO), sedentary males and females.
Age ≥ 18 and ≤ 55 years old.
BMI of 30-37 kg/m^2.
Waist-to-hip ratio of ≥ 0.95 in males and ≥ 0.90 in females.

Exclusion Criteria:

Any history of medications that impact adipocyte/lipid metabolism (e.g., niacin, TZD’s).
Smoking.
Insomnia.
Sleep apnea.
Sleep medication use.
Pregnancy (negative pregnancy test required).
Employment in night or shift work.

Eligibility last updated 9/9/21. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Kelli Lytle, Ph.D.	Closed-enrolling by invitation What is this? (?) "Close" Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.	Contact information: Pamela Reich (507) 255-6062 Reich.Pamela@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Kelli Lytle, Ph.D.

Closed-enrolling by invitation

Contact information:

Pamela Reich

(507) 255-6062

Reich.Pamela@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials