Clinical Trials

Inclusion Criteria:

• Age ≥ 18 years of age.
• Precapillary pulmonary hypertension with mean PA pressure > 20 mmHg and planned initiation of pulmonary arterial hypertension therapy.
• No active treatment for precapillary pulmonary hypertension.
• Ambulatory (not wheelchair / scooter dependent).
• Presence of any risk factor for left heart disease will qualify for inclusion (either atrial fibrillation, body mass index > 30 kg/m^2, arterial hypertension, diabetes, coronary artery disease or age > 60 years).

Exclusion Criteria:

• Significant chronic obstructive pulmonary disease that is a primary contributor to symptoms in the opinion of the investigator.
• Ischemia thought to contribute to dyspnea in the opinion of the investigator.
• Obstructive hypertrophic cardiomyopathy.
• Known infiltrative cardiomyopathy (amyloid).
• Constrictive pericarditis or tamponade.
• Active myocarditis.
• Complex congenital heart disease.
• More than mild aortic or mitral stenosis.
• Intrinsic (prolapse, rheumatic) valve disease with more than moderate mitral, tricuspid or aortic regurgitation.
• Acute or chronic severe liver disease as evidenced by any of the following: encephalopathy, variceal bleeding, INR > 1.7 in the absence of anticoagulation treatment.
• Terminal illness (other than HF) with expected survival of less than 1 year.
• Enrollment or planned enrollment in another therapeutic clinical trial in next 3 months.
• Inability to comply with planned study procedures.
• Pregnancy or breastfeeding mothers.