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Characterization of Biliary Cell-derived Organoids from Bile of PSC and Non-PSC Patients

Overview

About this study

The objectives of this study are to establish and perpetuate human biliary cell-derived organoids, to assess genetic and signaling pathway alterations in organoids derived from PSC patients as compared to Non-PSC patients, and to investigate the potential utility of organoids in the in vitro testing of experimental drugs.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

PSC

  • Patients diagnosed with Primary Sclerosing Cholangitis (PSC) between the age of 18 and 85.
  • The diagnosis of PSC will be based on standard PSC criteria including clinical and biochemical evidence of chronic cholestasis of at least six months duration, positive cholangiographic findings and compatible liver biopsies if available.
  • Women with PSC of childbearing potential and pregnant women will be offered enrollment because there is no risk to an unborn child in this investigation. Patients with PSC and Cholangiocarcinoma will be included.

Controls

  • Controls without history of PSC or evidence of other chronic liver disease of either gender that will participate in this study should be between the ages of 18-85. 

Exclusion Criteria: 

  • Patients unable to provide inform consent.
  • Prisoners and institutionalized individuals.
  • PSC with orthotopic  liver transplantation.
  • History of Roux En Y procedure.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Konstantinos Lazaridis, M.D.

Open for enrollment

Contact information:

Erik Schlicht CCRP

(507) 284-4312

Schlicht.Erik@mayo.edu

More information

Publications

Publications are currently not available

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CLS-20509170

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