A Study to Evaluate Home-Based Exercise as an Intervention for Treating Patients with Varying Levels of Kidney Function

Overview

About this study

The purpose of this research is to to determine whether home-based cardiac rehabilitation (CR) is an effective intervention to improve decreased physical function in patients with varying levels of kidney function. We will determine if home-based CR improves frailty parameters and SPPB scores. We will also determine if home-based CR improves health-related quality of life (HRQOL), body composition, physical activity, and adverse outcomes, including hospitalizations and death.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Age 18 years or older.
Consenting to research.
Chronic kidney disease (stages 1-5).
An SPPB score ≤ 10 or considered frail or pre-frail according to the Fried Frailty Phenotype.

Exclusion Criteria:

Younger than 18 years.
Patients being evaluated for combined organ transplantation.
Significant comorbidities that limit rehabilitation potential including pulmonary disease requiring continuous oxygen supplementation, active angina, critical aortic sclerosis, decompensated heart failure, or known ventricular arrhythmia.
An SPPB score > 10 or not considered frail or pre-frail by the Fried Frailty Phenotype.
Non-English speaker without availability of adequate interpreter services (safety concern).
Failure to pass submaximal exercise test in pateints not approved for kidney transplantation at our center.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Cassie Kennedy, M.D.	Closed for enrollment	Contact information: Elizabeth Lorenz M.D. (507) 284-2944 Lorenz.Elizabeth@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Cassie Kennedy, M.D.

Closed for enrollment

Contact information:

Elizabeth Lorenz M.D.

(507) 284-2944

Lorenz.Elizabeth@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials