Clinical Trials

Overview

About this study

The purpose of this pilot project is to investigate the relationship between localized brain stiffness values and functional brain activity in response to external stimuli (visual/motor).

Our current study proposes to investigate the effect of motor and or visual stimulus on the stiffness of the motor and visual cortex using a novel compact 3T MRI system having a high gradient slew rate. We plan to leverage the unique capability of the compact 3T system to be able to obtain functional images at a higher temporal resolution in comparison to the earlier studies which used a time scale of 18 seconds and above.

The short term goal of this study is to determine the relationship between the fMRI (T2* activation) and fMRE (stiffness) activation maps, with similar time scale of activation. In the long term, the study aims to establish fMRE (stiffness activation maps) as a complementary technique to fMRI which may allow us to unlock shorter-time scales and responses of the mechanical properties of the brain, which may provide diagnostic information that cannot be assessed with traditional fMRI.  Furthermore, since fMRE provides absolute stiffness estimates, it has the potential to become a more quantitative and sensitive metric for detecting regions of brain activation in comparison to conventional fMRI (BOLD) contrast.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Participating Mayo Clinic locations

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