Evaluation of F-18 Tetrafluoroborate (18F-TFB) PET/CT in Patients with Differentiated Thyroid Cancer

Overview

About this study

The purpose of this study is to investigate radiotracer 18F-tetrafluoroborate (18F-TFB) for imaging of patients with differentiated thyroid cancer

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Subject has biopsy-proven papillary or follicular thyroid cancer.
Subject is indicated for 123I-SPECT/CT total body iodine (TBI) scan.
Subject agrees to undergo 18F-TFB PET/CT scan following TBI scan.
Karnofsky performance status of greater than or equal to 50 (or ECOG/WHO equivalent).
Subject is able to be scanned - able to lie still on SPECT/CT and PET/CT scanner table for up to 65 min.
Age years 18 or older.
Ability to understand a written informed consent document, and the willingness to sign it.
Subject is not pregnant.

Exclusion Criteria:

Contrast-enhanced CT within 4 last weeks.
Amiodarone within last 4 months.
Ingested iodine, kelp tablets, Lugols iodine, or SSKI within 2 weeks. If questionable, then urinary iodine measurement must be performed. Exclude if 24h urinary iodine > 100 microg/d.
Unable to lie flat, still or tolerate a PET scan.
Applied betadine, iodoform, or quick tanning products to skin within last two weeks.
If using medication withdrawal for stimulation, then exclude if TSH level < 25.
Taken anti-thyroid medication within 1 week.
Subject is breastfeeding.
Positive pregnancy test.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Stephen Broski, M.D.	Closed-enrolling by invitation What is this? (?) "Close" Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.	Contact information: Jessica Brunn Brunn.Jessica@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Stephen Broski, M.D.

Closed-enrolling by invitation

Contact information:

Jessica Brunn

Brunn.Jessica@mayo.edu

More information

Publications

Publications are currently not available

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