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A Study to Evaluate the Intrarenal Microvessels in Autosomal Dominant Polycystic Kidney Disease

Overview

About this study

The primary objective of this study is to evaluate the use of Super-resolution ultrasound (SRU) to assess the intrarenal microvasculature in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria - Patients with ADPKD:

  • Male and female subjects, 18 - 40 years of age.
  • Previous diagnosis of ADPKD (based on Ravine et al. criteria).
  • Class 1 A-E according to imaging classification.
  • Estimated GFR > 70 mL/min/1.73 m^2 (CKD-EPI).
  • Ability to provide written, informed consent.

Exclusion Criteria:

  • Class 2 according to imaging classification.
  • Concomitant systemic disease affecting the kidney.
  • Diabetes mellitus.
  • Predicted urine protein excretion in > 1 g/24 hrs, and or Abnormal urinalysis.
  • Patients that are part on an interventional study or are taking tolvaptan.
  • Pregnant or lactating women.
  • History of hypersensitivity allergic reactions to ultrasound contrast agents.
  • High risk cardiac disease (such as unstable hospital in-patients or ICU patients.

Eligibility last updated 10/18/21. Questions regarding updates should be directed to the study team contact.

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Maria Irazabal Mira, M.D., Ph.D.

Open for enrollment

Contact information:

Genia Andrist

(507) 266-9594

Andrist.Genia@mayo.edu

More information

Publications

Publications are currently not available

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CLS-20524164

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