Mediterranean Diet Post-liver Transplantation

Overview

About this study

The purposes of this study are to prospectively evaluate the effects of a structured, modified Mediterranean diet on post-liver transplant weight gain and development of PTMS, to prospectively evaluate the effects of a structured, modified Mediterranean diet on cardiovascular outcomes post-liver transplantation, and to prospectively evaluate the effects of a structured, modified Mediterranean diet on development or recurrence or de novo NAFLD/NASH in liver-transplant patients.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

- Adult patients ≥ 18 years of age undergoing primary liver transplant

- Ascites-adjusted BMI ≥ 25 kg/m2

- Acceptable graft function (total bilirubin level < 5 mg/dL and doppler ultrasound with
patent hepatic artery, hepatic veins and portal veins)

Exclusion Criteria

- Hepatocellular carcinoma (HCC) that did not fulfill Milan criteria as per explant
histology

- Untreated post-transplant vascular complications or biliary strictures

- Multi-organ transplantation

- Urine protein excretion ≥2.0 g/day

- Uncontrolled diabetes mellitus (HbA1c > 10%)

- Associated medical conditions incompatible with safe participation in a nutritional
intervention study, including digestive diseases with fat intolerance, neurological,
psychiatric or endocrine disorders

- Active eating disorder (e.g. bulimia nervosa, anorexia nervosa)

- History of bariatric surgery

- Pregnancy or planning on pregnancy in the next year

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Kymberly Watt, M.D.	Open for enrollment	Contact information: Kymberly Watt M.D. Watt.Kymberly@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Kymberly Watt, M.D.

Open for enrollment

Contact information:

Kymberly Watt M.D.

Watt.Kymberly@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials