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Overview

About this study

To evaluate Subjects with Geographic Atrophy (GA), secondary to age-related Macular Degeneration (AMD) by sequencing selected genes associated with AMD. Subjects who meet eligibility criteria will have the option to participate in ongoing or future Gyroscope Therapeutics Limited (Gyroscope) sponsored studies.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Aged ≥ 55 years.
  • Able and willing to give consent to study participation.
  • Presence of unilateral or bilateral GA, secondary to AMD.

Exclusion Criteria:

  • History or evidence of choroidal neovascularisation (for example, wet AMD) in both eyes.  Subjects with CNV in only one eye may be included after approval from Gyroscope.
  • Currently receiving active treatment for CNV in either eye.
  • Presence of severe non-proliferative diabetic retinopathy or worse in either eye.
  • Have received any investigational product for the treatment of GA within the past 6 months, or 5 half-lives (whichever is longer) other than nutritional supplements such as the age-related eye disease study formula.
  • Received gene/cell therapy at any time previously.
  • Have any other significant ocular or non-ocular medical or psychiatric condition which,in the opinion of the Investigator, may either put the Subject at risk or may influence the results of the study.

Eligibility last updated 10/22/21. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Brittni Scruggs, M.D., Ph.D.

Closed for enrollment

More information

Publications

Publications are currently not available

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CLS-20529185

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