Clinical Trials

Inclusion Criteria:

- PRE-ELIGIBILITY - INCLUSION CRITERIA:

- Age >= 18 years

- Histological confirmation of newly diagnosed high-grade soft tissue sarcoma, or
recurrent high-grade soft tissue sarcoma >= 1-year post-treatment

- Tumors > 1 cm in diameter in largest dimension located midline within the torso or
neck, retroperitoneal, or lower extremities

- Operable sarcoma, planning to receive surgery with or without neoadjuvant
RT/chemotherapy at Mayo Clinic Florida. Systemic therapy is allowed during
radiotherapy

- Provide informed written consent

- Willingness to participate in mandatory imaging studies at Mayo Clinic Florida

Exclusion Criteria:

- POST-ELIGIBILITY - EXCLUSION CRITERIA:

- 18F-DOPA PET uptake deemed as unacceptable for quantitative assessment

- Unable to undergo an 18F-DOPA PET/MRI scan due to standard MRI restrictions, such as
for those with certain implanted devices, those who cannot fit inside the bore, or
those with severe claustrophobia

- Any of the following:

- Pregnant women

- Nursing women

- Men or women of childbearing potential who are unwilling to employ adequate
contraception

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 2/12/2024. Questions regarding updates should be directed to the study team contact.