Clinical Trials

Inclusion Criteria:

- Male or female, at least 18 years of age inclusive at the time of signing the ICF

- Must have NCFB diagnosed by a physician and confirmed by CT (measured at screening; if
a new CT is not possible, a CT performed within 12 months of the screening visit is
acceptable).

- Documented history of 2 or more bronchiectasis exacerbations within a year of the
screening visit.

- If receiving prophylactic systemic or inhaled antibiotics to prevent bronchiectasis
exacerbations, the dose/regimen must be stable for at least 3 months prior to the
screening visit and remain stable throughout the DB period of the study. If
prophylactic macrolides have been recently discontinued, patients must have been off
treatment for at least 3 months prior to randomisation. In all other cases of
prophylactic antibiotic use, ≥ 4 weeks wash out period should be in place after the
last dose of antibiotic and prior to randomisation

- Must be on airway clearance therapy, physiotherapy, or mucus clearance therapy.The
dose and regimen of these therapies and any drugs used to aid expectoration should be
stable for at least 3 months prior to the screening visit and remain stable throughout
the DB period of the study.

- If receiving inhaled corticosteroid or bronchodilator therapy, the dose and regimen
should be stable with no alteration to dose or formulation for at least 3 months prior
to the screening visit and this should remain stable throughout the DB period of the
study.

- Women of childbearing potential (WOCBP) must have a negative serum and urine pregnancy
test prior to randomization and agree to use a highly effective method of birth
control from enrollment, throughout the study duration, and for 12 weeks after the
last dose of IP.

Exclusion Criteria:

- Pulmonary disease other than bronchiectasis. Patients with a history of NTM disease
may be enrolled if they have completed treatment prior to the Screening visit, if at
least 3 months have elapsed since the last day of antibiotic treatment for NTM at the
Screening visit, and if they have had a negative sputum culture prior to the screening
visit.

- Another diagnosed or suspected pulmonary or systemic disease associated with elevated
peripheral eosinophil counts

- Respiratory infection or bronchiectasis exacerbation during the screening period.

- Any other clinical condition that is not stable in the opinion of the Investigator and
could:

1. Affect the safety of the patient during the study.

2. Influence the findings of the study or their interpretation.

3. Impede the patient's ability to complete the entire duration of the study.

- Radiological findings suggestive of a respiratory disease other than bronchiectasis,
suggestive of acute infection, or of solitary pulmonary nodules without appropriate
follow up and demonstration of stability as per standard of care. Pulmonary nodules >
6 mm in size should have at least 2 years of follow up with no change on CT imaging.

- Current active liver disease

- Current malignancy, or history of malignancy, except for:

1. Patients who have had basal cell carcinoma, localised squamous cell carcinoma of
the skin, or in situ carcinoma of the cervix are eligible provided the patient is
in remission and curative therapy was completed at least 12 months prior to Visit
1

2. Patients who have had other malignancies are eligible provided that the
participant is in remission and curative therapy was completed at least 5 years
prior to Visit 1.

- History of known immunodeficiency disorder including a positive test for human
immunodeficiency virus, HIV-1 or HIV-2.

- History of alcohol or drug abuse within the past year

- Current smokers with a tobacco history of ≥ 10 pack-years or ex-smoker with a tobacco
history of ≥ 10 pack-years.

- Patients receiving long-term oxygen treatment

- Patients participating in, or scheduled for, an intensive (active) pulmonary
rehabilitation programme. Patients who are in the maintenance phase of a
rehabilitation programme are eligible.

- Use of non-invasive positive-pressure ventilation for conditions other than
obstructive sleep apnoea

- Use of immunosuppressive medication within 3 months of the screening visit or expected
need for chronic use (≥ 4 weeks) during study

- Receipt of any marketed or investigational biologic products (monoclonal or polyclonal
antibody) within one year of the screening visit

- Receipt of any investigational non-biologic product within 30 days or 5 half-lives
prior to randomisation

- Receipt of immunoglobulin and blood products within 30 days of the date of the
screening visit

- Receipt of live attenuated vaccines within 30 days of the date of randomisation

- Concurrent enrolment in another clinical drug interventional trial

- History of anaphylaxis to any biologic therapy or vaccine

- Known history of allergy or reaction to any component of the IP formulation.

- Involvement in the planning and/or conduct of the study (applies to both AstraZeneca
staff and/or staff at the study site)

- Judgement by the Investigator that the patient should not participate in the study if
the patient is unlikely to comply with study procedures, restrictions, and
requirements

- Previous randomisation in the present study

- Currently pregnant (confirmed with positive pregnancy test) or breast-feeding.