Clinical Trials

Inclusion Criteria:

• Age ≥ 18 years.
• Stage 3 acute kidney injury according to the KDIGO criteria.
• Started or intending to start CKRT for volume management.
• Attending intensivist or nephrologist intending to remove fluid using CKRT for at least 48 hours.

Exclusion Criteria:

• Respiratory distress due to pulmonary edema or fluid overload.
• Massive volume infusion (i.e., > 200 mL/h for > 6 hours of continuous infusion).
• No intention to remove fluid as determined by attending intensivist or nephrologist.
• Attending intensivist or nephrologist believes that the protocol will not be followed.
• Continuous fluid removal for > 24 hours prior to study enrollment.
• Actual or estimated premorbid body weight > 120 kilograms.
• Patients treated with intermittent hemodialysis during the current admission.
• Patients on chronic outpatient hemodialysis. 
• Patients with history of, or current admission for kidney transplantation.
• Do not resuscitate, intubate, or comfort measures only orders (i.e., DNR/DNI/CMO).
• Moribund not expected to survive > 24 hours.
• Confirmed pregnancy.
• Patients treated with extracorporeal membrane oxygenation (ECMO), ventricular assist device (VAD), or intra-aortic balloon pump (IABP).
• Organ donors with neurological determination of death (i.e., brain dead donors).
• Drug overdose requiring CKRT.
• Enrollment in a concurrent interventional clinical trial with direct impact on fluid balance (e.g., > 500 mL study drug administration).

Eligibility last updated 3/9/22. Questions regarding updates should be directed to the study team contact.