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Exploratory Study of the Impact of Lactobacillus rhamnosus GG on Proton Pump Inhibitor-Induced Gut Dysbiosis

Overview

About this study

The purpose of this study is to observe how the addition of Lactobacillus rhamnosus GG effects changes to the fecal microbiota related to PPI use in healthy individuals.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Individuals on an unrestricted regular diet with no dietary restrictions (vegan, low FODMAP, gluten free, dairy-free etc) or other fad diets (e.g., keto, intermittent fasting, etc.).
  • Healthy subjects will be screened for current or chronic GI symptoms using a 16-item questionnaire.
  • Only those with an absence of symptoms will eligible to participate.

Exclusion Criteria:

  • For healthy volunteers, will include prior surgery altering the esophagus, stomach, and intestine (except appendectomy).
  • Chronic daily use of medications affecting GI secretion or motor function.
  • The presence of any GI-motility affecting systemic diseases or untreated psychiatric disease.
  • Pregnancy.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

John DiBaise, M.D.

Open for enrollment

Contact information:

Christine Bader

(480) 301-6767

Bader.Christine@mayo.edu

More information

Publications

Publications are currently not available

More about research at Mayo Clinic

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CLS-20536104

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