Dysfunction of Mesenchymal Stem/Stromal Cells Induced by Obesity

Overview

About this study

The purpose of this study is to determine how human obesity engages epigenetic mechanisms that impair human mesenchymal stem/stromal cells (MSC) mitochondrial structure and function and render MSC functionally deficient.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Group 1:
- Age 18-80 years;
- BMI ≥ 35 kg/m^2;
- Eligible for bariatric surgery;
- Ability to provide consent.
Group 2:
- Age 18-80 years;
- BMI ≤ 30 kg/m^2;
- Undergoing live donor nephrectomy;
- Ability to provide consent.

Exclusion Criteria:

Pregnancy.
Chronic Inflammatory Disease (e.g., rheumatoid arthritis).
Active malignancy.
Recent stroke or myocardial infarction.
Solid organ transplant recipients.
Therapeutic doses of immunosuppressive drugs (including calcineurin inhibitors and prednisone (> 10 mg/day).
Senolytic supplements.
Subjects on therapeutic doses of anticoagulants [including Warfarin (Coumadin), Rivaroxaban (Xarleto); Apixaban (Eliquis); Dabigatran (Pradaxa, Prazaxa)].
Subjects deemed ineligible to comply with study protocol.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Lilach Lerman, M.D., Ph.D.	Open for enrollment	Contact information: Department of Medicine (DOM) Research Hub (507) 266-1944 DOMRESEARCHHUB@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Lilach Lerman, M.D., Ph.D.

Open for enrollment

Contact information:

Department of Medicine (DOM) Research Hub

(507) 266-1944

DOMRESEARCHHUB@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials