Clinical Trials

Inclusion Criteria:

1. Male and female participants ≥ 18 years;

2. Informed consent form (ICF) read, signed, and dated prior to any study procedures
being performed;

3. Participants who fall into any one of the following categories:

1. Have been referred for an ICA directly of after non-invasive testing (e.g., SPECT
or PET MPI, stress echo, CCTA, ETT).

2. Had an ICA with no intervention. However, if any stenosis > 40% but ≤ 70% was
observed, an FFR or iFR assessment was performed.

3. Had a CCTA with normal coronaries or minimal CAD (no stenosis > 20%).

The SPECT study, PET 15O-H2O study, and ICA or CCTA testing need to be completed
within a 30-day window, with time 0 defined as the date of the first of these three
tests.

4. Women of Child Bearing Potential (WOCBP) must be non-pregnant, and non-lactating. For
women of childbearing potential, the results of a urine human chorionic gonadotropin
(HCG) pregnancy test (with the result known on the day of drug administration) must be
negative; these participants must be practicing appropriate birth control from time of
the screening visit until the end of the follow-up period. For women who are either
surgically sterile (have a documented bilateral tubal ligation or oophorectomy and/or
hysterectomy) or are post-menopausal (cessation of menses for more than 1 year),
enrollment in the study without a pregnancy test at screening is allowed.

5. Male will need to use contraceptive methods until end of the follow-up period.

6. Participants are able to comply with all study procedures as described in the
protocol.

Exclusion Criteria:

1. Participants are unable to undergo (even partially) any of the imaging procedures;

2. Participants with a known history of cardiac disease including:

1. myocardial infarction, previous coronary revascularization, or chronic ischemic
cardiomyopathy

2. primary myocardial disease such as cardiac amyloidosis or hypertrophic
cardiomyopathy

3. known left ventricular dysfunction

4. moderate or severe aortic or mitral stenosis or regurgitation

3. Participants in whom adenosine stress testing is contraindicated, including but not
limited to:

1. Participants with severe COPD or chronic asthma.

2. Participants with second- or third-degree atrioventricular block without a
pacemaker.

4. Participants with claustrophobia to an extent that would limit their ability to
undergo SPECT and PET imaging (patients whose claustrophobia is known to be readily
controlled with drugs or psychological support may be enrolled).

5. Participants who are on sildenafil (Viagra) or oral dipyridamole (Persantine,
Aggrenox) therapy and for whom its use cannot be terminated or suspended for ≥24 hours
prior to treatment of study drug.

6. Participants with significant co-morbidities that would prevent appropriate completion
of the protocol procedures.

7. Participants who have participated in another research study using investigational
drugs within the 30 days prior to enrollment or through the duration of the trial
(patients in observational studies with approved agents and participants known to be
on placebo may be enrolled).

8. Participants who have previously participated in this study.

9. Participants with a close affiliation with the investigational site, defined as a
close relative to the Investigator, or a dependent person such as an employee, student
or intern at the investigational site.

10. Subjects scheduled for, or planning to undergo, any interventional cardiac procedures
between enrollment and ICA (pathway 1) or signing of informed consent and 15O-H2O PET
MPI (pathway 2 and 3)

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 3/6/2024. Questions regarding updates should be directed to the study team contact.