Registry for Alzheimer’s Prevention in Wisconsin

Overview

About this study

The purpose of this study is to determine whether Alzheimer's Disease related cognitive trajectories can be identified in midlife and disambiguated from normal aging using serial cognitive measurement.

Additionally, to determine the biofluid and imaging biomarker profiles associated with cognitive trajectories and with eventual conversion to dementia; to determine the effect of genetic characteristics on cognitive decline, biomarkers and disease and health status; to determine the influence of lifestyle and health features that confers risk and resilience to AD; to make data available to local, national and international researchers and to facilitate WRAP participation in linked studies including imaging studies, brain bank, and intervention studies.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Aged 40-89.
Ability to speak English fluently and ability to understand and be willing to undergo study procedures for the entire length of the study.
Visual and auditory acuity adequate for neuropsychological testing.
A person who knows the participant well and can answer informant-based questionnaires and interviews.

Exclusion Criteria:

Major neurological disorders: A current diagnosis of dementia; certain other major and active diseases involving the brain such as Huntington’s disease.
Current major, severe, and/or unstable schizophrenia, bipolar, or other psychiatric disorder with psychotic features.
Lacks capacity to provide informed consent.

Exclusion Criteria for Roll-over and Follow-up Visits

Medical condition that makes cognitive testing not feasible or invalid as determined by the study team.

Eligibility last updated 01/29/2024. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
La Crosse, Wis. Mayo Clinic principal investigator Daniel Anderson, D.O.	Closed for enrollment	Contact information: Jodi Kaseno CCRP (608) 392-7187 Kaseno.Jodi@mayo.edu

Mayo Clinic Location

Status

Contact

La Crosse, Wis.

Mayo Clinic principal investigator

Daniel Anderson, D.O.

Closed for enrollment

Contact information:

Jodi Kaseno CCRP

(608) 392-7187

Kaseno.Jodi@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials