Clinical Trials

Inclusion Criteria:

• Age>17 and <79 years
• Any gender
• Patients with physician-diagnosed AERD (including a physician diagnosis of bilateral nasal polyposis, and at least one NSAID-induced reaction that caused respiratory symptoms)
• Patients with nasal polyps and no AERD (with and without asthma)
• Patients with diagnosed chronic rhinosinusitis without nasal polyps (regardless of asthma status)
• Patients who require endoscopic sinus surgery (ESS) for treatment of chronic rhinosinusitis and sinonasal polyposis as part of their standard of care treatment
• Patients that have active nasal polyps at the time of enrollment
• Healthy subjects without chronic sinusitis and require nasal rhinoscopy or transsphenoidal surgery for other reasons as a part of their standard of care.

Exclusion Criteria:

• Patients under the age of 17 years and above 79 years
• Patients who are or intend to get pregnant during the course of the study or those who are breastfeeding
• Patients with mental or legal incapacitation
• Patients with acute of chronic kidney or liver disease either self-reported or physician-diagnosed
• Patients with anemia requiring work-up up (hemoglobin <10 mg/dL)
• Patients with an active peptic ulcer disease
• Patients with bleeding-disorder or G6PD deficiency

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 10/07/2024. Questions regarding updates should be directed to the study team contact.