Human Brain Mapping to Understand Mechanisms of Learning, Memory, and Cognition

Overview

About this study

The mechanisms behind how we experience the world, form memories, and make future decisions is poorly understood. We perform an observational study of rare epilepsy patients implanted with electrocorticrographic (ECoG) and stereoencephalographic (sEEG) devices in our epilepsy monitor unit to record brain signals during cognitive and memory tasks. The neural signals recorded during these computerized tasks will be invaluable for not only to discover the mysteries of our cognition, but to also advance the next generation of future diagnostic or therapeutic strategies in countless neurological diseases that affect human cognition.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Patients with intractable epilepsy requiring placement of intracranial electrodes (grid, strip, or depth electrodes) for localization of seizure focus.
We estimate approximately 10 patients/year at current clinical volumes (per reports from 2017 and 2018)

Exclusion Criteria:

Patients who are physically or cognitively incapable of performing computer tasks.
Individuals with severe visual impairement, language disabilities, mentally challenged (IQ < 70), and others with cognitive impairments.
All patients 2002 through to the present.
All candidates who have undergone conventional resective epilepsy surgery requiring implanted electrodes met the inclusion criteria for the present proposed study.
Inclusion/exclusion criteria are not expected to have a negative influence on recruitment.

Eligibility last updated 12/21/21. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Jacksonville, Fla. Mayo Clinic principal investigator Sanjeet Grewal, M.D.	Open for enrollment	Contact information: Seung Lee M.D. (904) 953-2000 Lee.Seung@mayo.edu

Mayo Clinic Location

Status

Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Sanjeet Grewal, M.D.

Open for enrollment

Contact information:

Seung Lee M.D.

(904) 953-2000

Lee.Seung@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials