A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection

Overview

About this study

The purpose of this research is to compare sympathetic function (flight or fight system), arterial structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.

The sympathetic function across the menstrual cycle in premenopausal women with a history of SCAD will also be compared to age-matched premenopausal women.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

- For SCAD patients: history of SCAD as confirmed by coronary angiography or cardiac
computed tomography angiography

- For controls: no cardiac disease history

Exclusion Criteria:

- Pregnancy

- Known or suspected unstable cardiac condition within 4 weeks of the study

- Active treatment with anticoagulation or dual antiplatelet therapy

- Prisoner

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 2/14/2024. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Marysia Tweet, M.D., M.S.	Closed-enrolling by invitation What is this? (?) "Close" Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.	Contact information: Pamela Engrav (507) 255-6938 Engrav.Pamela@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Marysia Tweet, M.D., M.S.

Closed-enrolling by invitation

Contact information:

Pamela Engrav

(507) 255-6938

Engrav.Pamela@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials