Predicting Disease Progression in Pediatric Patients With Autosomal Dominant Polycystic Kidney Disease Using Urinary Crystal Burden as a Biomarker

Overview

About this study

The purpose of this study is to characterize urinary crystalluria, supersaturation, cytokines, and extracellular vehicles from activated renal tubular epithelial cells, interstitial monocytes, and pro-and anti-inflammatory macrophages in a cohort of male and female pediatric patients with autosomal dominant polycystic kidney disease (ADPKD). Also, to determine cross-sectional associations between cyst burden/kidney function and urinary crystalluria, supersaturation, cytokines, and extracellular vehicles (EVs).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Any autosomal dominant polycystic kidney disease (ADPKD) patient (ages 5-18 years) with confirmed ADPKD (via a combination of imaging, family history, and/or genetic testing), identified from existing and newly identified families for the proposed study.
Matched controls will be identified as unaffected siblings, unaffected family members of ADPKD subjects, or children recruited from the outpatient primary care clinics.

Exclusion Criteria:

ADPKD patients with liver and or kidney transplant.

Eligibility last updated 10/6/22. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Christian Hanna, M.D., M.S.	Open for enrollment	Contact information: Ryan Helland (507) 422-3998 Helland.Ryan@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Christian Hanna, M.D., M.S.

Open for enrollment

Contact information:

Ryan Helland

(507) 422-3998

Helland.Ryan@mayo.edu

More information

Publications

Publications are currently not available

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