Clinical Trials

Inclusion Criteria:

• Premenopausal women, ages 18-50 years old.
• Uterine fibroid group (n≈20): These participants will have had a previous or current diagnosis of UF determined by ultrasound, hysteroscopy, or MRI, confirmed with medical documentation within one year of recruitment.
• Control (non-fibroid) group (n≈20): These participants will not have evidence of UF (confirmed by imaging) at the time of study participation.

Exclusion Criteria:

• History or evidence of:
  • hepatic, renal, or hematological disease;
  • peripheral vascular disease;
  • stroke/neurovascular disease;
  • diabetes;
  • dyslipoproteinemia;
  • hypertension (> 130/80 mmHg brachial cuff pressure); 
  • lung disease;
  • arthritis affecting ability to exercise; or
  • a body mass index > 30 kg/m^2. 
• Participants also will be excluded if taking antihypertensive medication or medication that alters autonomic or vascular function (e.g., tricyclic antidepressants, alpha-blockers, beta-blockers, etc.). 
• Participants will be non-smokers. 
• Subjects must have a negative pregnancy test in order to participate in the study. 
• Participants who are breastfeeding will be excluded.
• Women who have undergone hysterectomy will be excluded.

Eligibility last updated 3/7/22. Questions regarding updates should be directed to the study team contact.