Spasticity After Spinal Cord Injury

Overview

About this study

A growing body of research demonstrates a correlation between residual corticospinal connectivity and severity of spasticity following SCI (Sangari et al., 2019b). The purpose of this study is to analyze this correlation to better understand the relationship between spasticity as a biomarker of residual corticospinal connectivity and neurologic and functional recovery.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion criteria for individuals with SCI

* Chronic SCI (≥1 year of injury)
* Incomplete spinal cord injury at T12 or above
* Males and Females
* Ages 18-75 years

Inclusion criteria for non-spastic individuals with SCI

-MAS scores of 0 and 1

Inclusion criteria for spastic individuals with SCI

* MAS scores of 2, 3 and 4
* The ability to perform a voluntary flexion and extension of the elbow and/or knee or ankle
* The ability to reach and grasp an object

Inclusion criteria for health controls

* Males and females
* Ages 18-75 years
* Right-handed
* Able to perform elbow and/or knee or ankle flexion and extension

Exclusion Criteria for individuals with SCI and healthy controls:

* Uncontrolled medical problems including pulmonary, cardiovascular, or orthopedic disease
* Any debilitating disease prior to the SCI that caused exercise intolerance
* Premorbid, ongoing major depression or psychosis, altered cognitive status
* History of head injury or stroke
* Pacemaker
* Metal plate in skull
* History of seizures
* Receiving drugs acting primarily on the central nervous system, which lower the seizure threshold such as antipsychotic drugs (chlorpromazine, clozapine) or tricyclic antidepressants
* Pregnant females
* Ongoing cord compression or a syrinx in the spinal cord or who suffer from a spinal cord disease such as spinal stenosis, spina bifida, or herniated cervical disk

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Ronald Reeves, M.D.	Open for enrollment	Contact information: Tyson Scrabeck CCRP (507) 538-1016 Scrabeck.Tyson@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Ronald Reeves, M.D.

Open for enrollment

Contact information:

Tyson Scrabeck CCRP

(507) 538-1016

Scrabeck.Tyson@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials