Progressive Supranuclear Palsy Gait and Balance Impairment in Mechanisms

Overview

About this study

The purpose of this study is to determine objective measures of gait and balance impairment in PSP syndromes using laboratory-based motion analysis.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adults over age 18 only.
  • Normal controls will include individuals over the age of 18, who provide informed consent for gait analysis and do not have any medical condition affecting their gait and balance.
  • Patients with Progressive Supranuclear Palsy (PSP):
    • Patients over the age of 35 meeting the 2017 Movement disorders society criteria for PSP will be recruited. To be able to participate in the gait analysis patients must be able to ambulate with or without a gait aid. Patients will be identified from the neurology clinic, where the PI commonly sees this condition.

Exclusion Criteria: 

  • Subjects will be excluded if they do not have the symptoms necessary to fulfill inclusion criteria for PSP.
  • Individuals with PSP at very advanced disease stage who are no longer ambulatory or are wheelchair bound excluded.
  • Subjects with concurrent illnesses that could account for their gait and balance abnormality such as traumatic brain injury, encephalitis, strokes, amputation, injury or developmental syndromes will be excluded. Women that are pregnant or post-partum and breast-feeding will be excluded.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 5/10/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Farwa Ali, M.B.B.S.

Open for enrollment

Contact information:

Christine Deml CCRP

(507) 266-0984

Deml.Christine@mayo.edu

More information

Publications

Publications are currently not available
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CLS-20549665

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