Humans With Obesity Response to Exercise

Overview

About this study

Fat tissue was once believed to be only important for storing energy, but we are now learning that fat tissue released a large number of molecules that can affect other tissues. Muscles may be affected by fat that accumulates in the abdominal area and around the muscles themselves. This project seeks to understand how fat tissue may influence important functions o muscles.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

* Obese men and women ≥ 20 and ≤ 45 years of age.

Exclusion Criteria:

* Diabetes or fasting plasma glucose \>126 mg/dL
* Anemia (female subjects hemoglobin of \<11 g/dl and male subjects hemoglobin \<12 g/dl)
* Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment)
* Renal failure (serum creatinine \> 1.5mg/dl)
* Chronic active liver disease defined as aspartate aminotransferase (AST)\>144 IU/L or alanine transaminase (ALT) \>165 IU/L)
* Oral warfarin group medications or history of blood clotting disorders.
* Smoking
* Pregnancy or breastfeeding
* Alcohol consumption greater than 2 glasses/day or other substance abuse
* Untreated or uncontrolled hypothyroidism
* Debilitating chronic disease (at the discretion of the investigators)

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 9/26/2024. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Ian Lanza, Ph.D.	Open for enrollment	Contact information: Rachel Passehl (507) 255-8112 Passehl.Rachel@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Ian Lanza, Ph.D.

Open for enrollment

Contact information:

Rachel Passehl

(507) 255-8112

Passehl.Rachel@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials