Clinical Trials

Inclusion Criteria - PAD Patients:

• Mild claudication to minor tissue loss (Rutherford 1-5).
• Resting or exercise ankle-brachial index < 0.9 or toe brachial index < 0.6.
• Age 35 or more.

Inclusion Criteria - Healthy Volunteers:

• Age 35-90.

Exclusion Criteria - PAD Patients and Healthy Volunteers: 

• Evidence of active infection.
• Chronic liver disease, end-stage renal disease (CKD 5), or chronic inflammatory disease.
• Poorly controlled diabetes (HbA1c > 8%).
• BMI < 18 or > 35.
• Recent other major surgery or illness within 30 days.
• Use of immunosuppresive medications or steroids.
• History of organ transplantation.
• Pregnancy, or plans to become pregnant, or lactating.

Exclusion Criteria - Healthy Volunteers:

• hsCRP > 2 mg/L.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 5/19/23. Questions regarding updates should be directed to the study team contact.