Gut-Brain Axis for Improving Psychocognitive Health Outcomes of Critical Illness Survivors

Overview

About this study

The purpose of this study is to to evaluate feasibility of high fermented food diet among critical illness survivors and its effect on microbiome diversity. Also, to evaluate the effect of high fermented food diet on immune system performance and recovery, mental health, cognition, and quality of life of critical illness survivors.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

- patients who have survived critical illness, including severe COVID, and are at risk for mental health morbidity/long COVID (spent \>48 hours in the ICU or had COVID requiring ICU stay) who have a smartphone, are enrolled into the Mayo PICS clinic, and have at least one PICS-related impairment. Cognitive impairment, if present, has to be in the mild range to ensure patient can provide consent and follow study instructions

Exclusion Criteria:

- History of dementia, mental retardation, psychotic disorders such as schizophrenia, patients not expected to survive the hospital stay or non-English speaking, participants not able to tolerate foods by mouth or those with potential contraindications to such diet (chronically immunosuppressed including organ transplant recipients; those with neutropenia or currently undergoing chemotherapy, those taking Monoamine oxidase inhibitors).

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 11/06/2024. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Lioudmila Karnatovskaia, M.D.	Open for enrollment	Contact information: Andrea Johnson APRN, C.N.P. (507) 266-7513 Walker.Andrea@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Lioudmila Karnatovskaia, M.D.

Open for enrollment

Contact information:

Andrea Johnson APRN, C.N.P.

(507) 266-7513

Walker.Andrea@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials