A Study of Breath Testing for Small Intestinal Bacterial Overgrowth

Overview

About this study

The purpose of this study is to assess the incidence of small intestinal bacterial overgrowth (SIBO) in patients with symptoms of gastroesophageal reflux disease treated with proton pump inhibitors.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion criteria:

* Predominant symptoms of gastroesophageal reflux disease including heartburn, regurgitation
* Subjects must be able to give appropriate informed consent

Exclusion criteria:

* Prior diagnosis of SIBO
* Use of PPIs or H2R-anatagonstists in the prior 3 months
* Major concomitant illness (renal, hepatic, rheumatologic or cardiovascular disease, or malignancy)
* Antibiotic therapy within one month
* Prior gastrointestinal surgery including esophageal, gastric, and small or large bowel surgery
* Previously diagnosed irritable bowel syndrome or inflammatory bowel disease
* Individuals who are pregnant or breast feeding
* Patients with plans to become pregnant
* Inability to take PPIs, including allergy/sensitivity

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 5/07/2024. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Jacksonville, Fla. Mayo Clinic principal investigator Andree Koop, M.D.	Open for enrollment	Contact information: Andree Koop M.D. (904) 953-6970 Koop.Andree@mayo.edu

Mayo Clinic Location

Status

Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Andree Koop, M.D.

Open for enrollment

Contact information:

Andree Koop M.D.

(904) 953-6970

Koop.Andree@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials